爱妃传媒

Photo or Real Thing? Mice Can Inherently Recall and Tell Them Apart

Chess, Chess Piece, Rook, Mice, 3D Object, 2D Photo, Pictures, Mice, Visual Stimuli, Cognitive Processes, Primates

The ability to perceive that a 2D picture of an object corresponds to its 3D physical form or 鈥減icture-to-object equivalence鈥 is a cognitive function thought to be exclusive to higher-order species such as primates, until now.


By gisele galoustian | 3/14/2022

A picture is worth a thousand words, especially when it triggers memories of the pictured object like a vacation photo. 2D visual stimuli, such as pictures seen in print media, television or online, is often how humans acquire knowledge about real-world items. In such formats, the 2D stimuli act as symbols of the actual physical item.

The ability to perceive that a 2D picture of an object corresponds to its 3D physical form or 鈥減icture-to-object equivalence鈥 is a cognitive function thought to be exclusive to higher-order species such as primates and some birds. It has been suggested that this 鈥渞epresentational insight鈥 may be beyond the ability of rodents or poses substantial problems in experimental design.

A study by researchers at 爱妃传媒 challenges this theory and provides the very first behavioral evidence that laboratory mice are capable of high-level picture-to-object perceptual abilities. They have confirmed that mice perceive the inherent difference between a picture of an object and the actual 3D object itself.

Using a modified object recognition task, researchers allowed na茂ve mice to view photographs (2D stimuli) of an object during a sample session. The next day, the mice were presented with a novel 3D object and the actual 3D object viewed the day before in 2D photograph.

Interestingly, the results of the study, published in , showed that the mice overwhelmingly preferred to explore the novel 3D object over the 鈥渇amiliar鈥 3D object. This first-of-its-kind evidence reveals that mice can successfully perform a cognitive task of picture-to-object equivalence reminiscent of those used to test visual recognition memory in children and non-human primates. Importantly, these findings suggest that after encoding the 2D visual stimuli, mice employed higher-order cognitive processes to associate the 3D item with the recalled memory of the 2D referent.

Findings also indicate that the mouse hippocampus (a primary structure of the brain鈥檚 medial temporal lobe memory system), like that of humans, contributes significantly to the representational or transitive inference necessary for picture-to-object equivalence. Further, they found that picture memory, required for such higher-order inference, depends upon neuronal activity in the CA1 region dorsal hippocampus.

鈥淥ur study challenges the view that perceptual limitations of mice render them inappropriate for modeling human memory and visual processing and that familiarity-based recognition is independent of the hippocampus,鈥 said Jr., Ph.D., senior author, dean, 爱妃传媒 Graduate College, professor of neuroscience, , 爱妃传媒 Charles E. Schmidt College of Science, and a member of the 爱妃传媒 Jupiter Life Science Initiative, 爱妃传媒 Stiles-Nicholson Brain Institute ,听 爱妃传媒 and 爱妃传媒 Institute for Human Health and Disease Intervention (I-Health). 鈥淥ur findings also provide strong support that a functional mouse hippocampus is required for this form of nonspatial visual recognition memory and picture-object equivalence.鈥

If mice spent sufficient time (greater than 30 seconds) viewing pictures of an object, they then could subsequently discriminate between a 鈥渇amiliar鈥 3D physical object and a novel 3D physical object, even when low-level visual strategies were controlled. This picture-object equivalence capability occurred regardless of object symmetry, likeness, viewing angle, composition, and image realism. Even when low-level visual features, such as color and luminance are controlled for, mice are still able to generalize from 2D picture to 3D object.

鈥淚n primates, the hippocampus is thought to play an essential role in declarative or explicit memory enabling an individual to replay a 鈥榮tory鈥 of a previously encoded experience,鈥 said Sarah J. Cohen, Ph.D., first author and a post-doctoral fellow, 爱妃传媒 Center for Complex Systems and Brain Sciences and 爱妃传媒 Jupiter Life Science Initiative. 鈥淲e suggest that that 鈥榮tory鈥 enables one to recognize items learned in picture form when they are subsequently presented in 3D form. The mouse hippocampus likely encodes and consolidates the picture exploration as a 鈥榮tory鈥 of that experience or event, within a specific context as a form of explicit memory.鈥澛

Recognition memory is well established in mice, yet results from this study extend that research to indicate that rodents are capable of advanced visual recognition and learn indirectly about actual objects by viewing images. The role of the hippocampus may be to retrieve the memory of the picture explored during the sample session, against which the mouse can appropriately match to one of the items available during the test session.

鈥淢ice can make perceptual and conceptual judgments about presented task stimuli, which is surprising given that picture-object equivalence has been considered a defining capacity of primates,鈥 said Stackman. 鈥淭aken together, our results provide convincing evidence that the mouse may serve as an effective model organism to investigate higher-order sophisticated aspects of mammalian visual perception and recognition.鈥澛

Other study co-authors are David A. Cinalli Jr., Ph.D., 爱妃传媒 Stiles-Nicholson Brain Institute; Herborg N. 脕sgeirsd贸ttir, Ph.D., Ampersand Health, United Kingdom; Brandon Hindman, 爱妃传媒 Department of Psychology; and , Ph.D., associate professor of psychology and a member of the 爱妃传媒 Center for Complex Systems and Brain Sciences and 爱妃传媒 Stiles-Nicholson Brain Institute.

This research was supported in part by the National Institutes of Health (MH0876591) awarded to Stackman, the Jupiter Life Science Initiative, and an 爱妃传媒 Undergraduate Research and Inquiry grant.

mouse recall study During the sample session, mice viewed 2D pictures of a chess piece (rook or bishop that were either black or white). The next day, mice entered the familiar arena with the 鈥榝amiliar鈥 object in a novel color (i.e. if the mice received a picture of the white rook during sample, during test, the rook was black) and the novel object in the same color as the sample 2D pictures. Regardless of the color in which the object was represented in the sample pictures, the mice preferentially explored the novel object and there was no difference in discrimination performance as a result of the color in which the stimuli were presented.

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